- Link:
- http://hdl.handle.net/10204/4222
- Collection:
-
- Subjects
- Oxygen carrier Nanoemulsion Organ preservation CSIR Conference 2010
- Creators:
- Naidoo, K Moolman, S Msomi, S Barnard, A
- Publisher
- CSIR
- Type
- Poster
- Language
- en
- Description
- The current key development focus in organ
preservation for transplant purposes is preservation of organs at
normothermic or subnormothermic temperatures (i.e at or slightly
below physiological temperature) as opposed to cold storage. The
current gold standard in organ preservation for transplant is to
preserve harvested organs at low temperatures while circulating an
organ preservation solution through the organ. The organs however,
sustain some damage when exposed to such low temperatures, a
phenomenon known as ‘cold perfusion damage’. It is therefore
desirable to transport the organ at temperatures closer to normal
physiological conditions (i.e 25 to 37 °C). This however,
substantially increases the organ’s oxygen requirement levels. A
critical aspect of organ preservation at higher temperatures is
thus the provision of a sufficient oxygen supply to the harvested
organ so that the organ can maintain its metabolic rate and remain
a viable candidate for transplant. The CSIR has developed a
synthetic perfluorocarbon (PFC) based nanoemulsion that serves as
an oxygen carrier for the preservation of organs.
Perfluorochemicals can be used as oxygen carriers due to their
exceptionally high capacity to dissolve gasses1,2. Additionally,
PFC’s display high levels of chemical stability and biological
inertness which makes them suitable for biological use1,2.
Perfluorooctyl bromide (PFOB) is the particular PFC used in the
CSIR oxygen carrier emulsion1,2.
- Description
- CSIR 3rd Beinnual Conference 2010, Science Real and
Relevant, CSIR International Convention Center, Pretoria, South
Africa
- Access:
- Instructions in case access is denied
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