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1. A central composite design to investigate antibody fragment production by Pichia pastoris

Chan, Joyce, M. Eng. Massachusetts Institute of Technology,

This study aims to investigate the relationships between growth parameters (agitation, glycerol concentration, salt concentration) and responses (biomass, growth rate, protein expression), by a 3-fact...

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2. A dendrimer-based prodrug for use in an anti-cancer nanocell

Awasthi, Samir,

Cancer science is a heavily researched and rapidly changing field. Cutting edge research consistently reveals unique features of tumors that can be exploited for treatment. For example, it is well kno...

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3. A microfluidic platform for three-dimensional neuron culture, microfluidic platform for 3-D neuron culture

Varner, Johanna (Johanna M.),

Neurodegenerative diseases typically affect a limited number of specific neuronal subtypes, and the death of these neurons causes permanent loss of a specific motor function. Efforts to restore functi...

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4. A modeling framework and toolset for simulation and characterization of the cochlea within the auditory system

Alkhairy, Samiya Ashraf,

Purpose: This research develops a modeling approach and an implementation toolset to simulate reticular lamina displacement in response to excitation at the ear canal and to characterize the cochlear ...

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5. A new mouse model to probe the role of aflatoxin B₁ in liver carcinogenesis

Bouhenguel, Jason T,

One and a half million new cancer cases are reported each year in the United States. Despite this overwhelming burden of disease, current preventative treatments and early detection techniques are ina...

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6. A novel bioengineering platform using functionalized self-assembly peptides to enhance CYP3A2 activity in modified rat hepatocyte sandwich cultures

Wu, Jonathan (Jonathan G.),

Isolated hepatocytes removed from their microenvironment soon lose their hepatospecific functions when cultured. Highly oxygen-demanding hepatocytes are commonly maintained under oxygen-deficient cult...

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7. A novel high-throughput in-cell Western assay for the quantitative measurement of signaling dynamics in DNA damage signaling networks : cell decision processes in response to DNA double strand breaks, Cell decision processes in response to DNA DSB

Tentner, Andrea R. (Andrea Ruth),

Following exposure to DNA damage, cells initiate a stress response involving multiple protein kinase signaling cascades. The DNA damage response results in one of several possible cell-fate decisions,...

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8. A novel nanodelivery system for combination tumor therapy

Eavarone, David A. (David Alan),

Anti-angiogenic therapy offers many benefits over traditional cytotoxic chemotherapy including fewer toxic side effects and the reduced development of drug resistance. Anti-angiogenics alone have not ...

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9. A quantitative proteomics study of the additive effect of inflammatory cytokines and injurious compression on cartilage damage

Swaminathan, Krishnakumar,

Objectives: 1) To perform a quantitative comparison of proteins released to media on combination with cytokine (IL-1[beta[ or TNF-[alpha]) and Injury as compared to either treatment alone, and to thus...

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10. A study of inter-individual differences in the DNA damage response

Sefta, Meriem,

Agents that damage our DNA are omnipresent in our environment and inside our cells themselves. Left unrepaired, DNA damage can lead to premature aging, neurodegeneration and cancer. Humans have thus e...

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