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61. UML Activity Diagram-Based Automatic Test Case Generation For Java Programs

Chen, Mingsong, Qiu, Xiaokang, Xu, Wei, Wang, Linzhang, Zhao, Jianhua, Li, Xuandong,

Test case generation based on design specifications is an important part of testing processes. In this paper, Unified Modeling Language activity diagrams are used as design specifications. By setting ...

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62. Construct and criterion validity of several proposed DAS28-based rheumatoid arthritis flare criteria: an OMERACT cohort validation study

van der Maas, Aatke, Lie, Elisabeth, Christensen, Robin, Choy, Ernest, de Man, Yaël A, van Riel, Pie...

Background To describe rheumatoid arthritis (RA) worsening that leads to change or re-initiation of treatment, several Disease Activity Score 28 (DAS28)-based flare criteria have been de...

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63. Persistence of Type-Specific Human Papillomavirus Infection and Increased Long-term Risk of Cervical Cancer

Chen, Hui-Chi, Schiffman, Mark, Lin, Ching-Yu, Pan, Mei-Hung, You, San-Lin, Chuang, Li-Chung, Hsieh,...

Background Human papillomavirus (HPV) persistence is the pivotal event in cervical carcinogenesis. We followed a large-scale community-based cohort for 16 years to investigate the role o...

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64. Evaluation of in Vitro Reporter Gene Induction Assays for Use in a Rapid Prescreen for Compound Selection to Test Specificity in the Tg.AC Mouse Short-Term Carcinogenicity Assay

Thompson, Karol L., Rosenzweig, Barry A., Tsong, Yi, Sistare, Frank D.,

Under ICH guidelines, short-term carcinogenicity assays such as the Tg.AC assay are allowed alternatives for one species in the 2-year rodent bioassay. The Tg.AC transgenic mouse, which carries the v-...

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65. Classification of test agent-specific effects in the Syrian hamster embryo assay (pH 6.7) using infrared spectroscopy with computational analysis

Ahmadzai, Abdullah A., Trevisan, Júlio, Pang, Weiyi, Patel, Imran I., Fullwood, Nigel J., Bruce, Sha...

The Syrian hamster embryo (SHE) cell transformation assay (pH 6.7) has utility in the assessment of potential chemical carcinogenicity (both genotoxic and non-genotoxic mechanisms of action). The assa...

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66. Classification of test agent-specific effects in the Syrian hamster embryo assay (pH 6.7) using infrared spectroscopy with computational analysis

Ahmadzai, Abdullah A., Trevisan, Júlio, Pang, Weiyi, Patel, Imran I., Fullwood, Nigel J., Bruce, Sha...

The Syrian hamster embryo (SHE) cell transformation assay (pH 6.7) has utility in the assessment of potential chemical carcinogenicity (both genotoxic and non-genotoxic mechanisms of action). The assa...

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67. Laboratory testing policies and their effects on routine surveillance of community antimicrobial resistance

Heginbothom, Margaret L., Magee, J. T., Bell, Joanna L., Dunstan, F. D. J., Howard, A. J., Hillier, ...

Objective: To investigate the effects of laboratory testing policies, particularly selective testing, rule-based reporting and isolate identification, on estimates of community antimicrobial re...

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68. Tissue-specific prediction of directly regulated genes

McLeay, Robert C., Leat, Chris J., Bailey, Timothy L.,

Direct binding by a transcription factor (TF) to the proximal promoter of a gene is a strong evidence that the TF regulates the gene. Assaying the genome-wide binding of every TF in every cell type an...

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69. Context-specific microRNA analysis: identification of functional microRNAs and their mRNA targets

Bossel Ben-Moshe, Noa, Avraham, Roi, Kedmi, Merav, Zeisel, Amit, Yitzhaky, Assif, Yarden, Yosef, Dom...

MicroRNAs (miRs) function primarily as post-transcriptional negative regulators of gene expression through binding to their mRNA targets. Reliable prediction of a miR’s targets is a considerable bioin...

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70. Use of a Direct Fluorescent Antibody Test for Detecting Chlamydia trachomatis Cervical Infection in Women Seeking Routine Gynecologic Care

Phillips, Russell S., Hanff, Philip A., Kauffman, Robert S., Aronson, Mark D.,

We determined the sensitivity, specificity, and predictive value of a direct fluorescence test for Chlamydia trachomatis infectioncompared with culture of the endocervix in women seeking rout...

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