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1. Seeding efficiency of primitive human hematopoietic cells in nonobese diabetic/severe combined immune deficiency mice: implications for stem cell frequency assessment

Hennik, P.B. van, Koning, A.E. de, Ploemacher, R.E.,

Nonobese diabetic/severe combined immune deficiency (NOD/SCID) mouse repopulating cells (SRC) have been proposed to represent a more primitive human stem cell subset than the cobblestone area-forming ...

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2. Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system.

Little, Mark A, Al-Ani, Bahjat, Ren, Shuyu, Al-Nuaimi, Hamad, Leite, Maurilo, Alpers, Charles E, Sav...

Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). Pro...

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3. Homologous and non-homologous recombination differentially affect DNA damage repair in mice

Essers, J., Steeg, H. van, Wit, J. de, Swagemakers, S.M.A., Vermeij, M., Hoeijmakers, J.H.J., Kanaar...

Ionizing radiation and interstrand DNA crosslinking compounds provide important treatments against cancer due to their extreme genotoxicity for proliferating cells. Both the efficacies of such treatme...

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4. Homologous and non-homologous recombination differentially affect DNA damage repair in mice.

Essers, J., Steeg, H. van, Wit, J. de, Vermeij, M., Hoeijmakers, J.H.J., Kanaar, R., Swagemakers, S....

Ionizing radiation and interstrand DNA crosslinking compounds provide important treatments against cancer due to their extreme genotoxicity for proliferating cells. Both the efficacies of such treat...

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5. Acute serum amyloid A induces migration, angiogenesis, and inflammation in synovial cells in vitro and in a human rheumatoid arthritis/SCID mouse chimera model.

Connolly, Mary, Marrelli, Alessandra, Blades, Mark, McCormick, Jennifer, Maderna, Paola, Godson, Cat...

Serum amyloid A (A-SAA), an acute-phase protein with cytokine-like properties, is expressed at sites of inflammation. This study investigated the effects of A-SAA on chemokine-regulated migration and ...

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6. From bone marrow to airways in allergen-induced airway inflammation

Johansson, Anna-Karin 1974-,

The airway (AW) inflammation in asthma includes eosinophils, neutrophils and T-lymphocytes. The accumulation of inflammatory cells within the AW is considered to be a result of increased production of...

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7. Development and transplantation of a mineralized matrix formed by osteoblasts in vitro for bone regeneration

Xiao, Y., Haase, H. R., Young, W. G., Bartold, Mark,

The use of extracellular matrix materials as scaffolds for the repair and regeneration of tissues is receiving increased attention. The current study was undertaken to test whether extracellular matri...

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8. TH1/TH2,3 imbalance due to cytokine-producing NK, γδ T and NK-γδ T cells in murine pregnancy decidua in success or failure of pregnancy

Clark, D. A., Croitoru, K.,

Problem: Recurrent spontaneous abortion in DBA/2-mated CBA/J mice has been attributed to the production of Th1 cytokines (tumor necrosis factor [TNF]-α and interferon [IFN]-γ) by asialoGM1+ natural ki...

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9. The microenvironmental organization of early B cell precursors in the femoral bone marrow of mutant SCID mice, SCOD/myc transgenic mice and alternate fraction x-irradiated endocolonized mice /

Manoukian, Raffi,

The in situ microenvironmental organization of early precursor B cells in mouse bone marrow has been studied using three experimental models: (1) mutant mice with severe combined immunodeficiency (SCI...

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10. Regulation and deletion of early B lineage precursor cells (pro-B cells) in the bone marrow of mice with severe combined immunodeficiency (SCID)

Kim, Hak Lim Nancy,

Mice homozygous for the scid (severe combined immunodeficiency) mutation are generally unable to produce B lymphocytes, a condition attributed to defective rearrangements of immunoglobulin genes in pr...

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