Adamson, Peter C.

Creator of the following documents

1. Plasma pharmacokinetics and cerebrospinal fluid penetration of thioguanine in children with acute lymphoblastic leukemia: a collaborative Pediatric Oncology Branch, NCI, and Children's Cancer Group studyPlasma pharmacokinetics and cerebrospinal fluid penetration of thioguanine in children with acute lymphoblastic leukemia: a collaborative Pediatric Oncology Branch, NCI, and Children's Cancer Group study

Purpose: In preclinical studies, thioguanine (TG) has been shown to be more potent than the standard acute lymphoblastic leukemia (ALL) maintenance agent, mercaptopurine (MP), suggesting that TG may b...

2. Treatment of Accidental Intrathecal Methotrexate Overdose With Intrathecal Carboxypeptidase G2Treatment of Accidental Intrathecal Methotrexate Overdose With Intrathecal Carboxypeptidase G2

The bacterial enzyme carboxypeptidase G2 (CPDG2) rapidly hydrolyzes methotrexate to inactive metabolites. We administered recombinant CPDG2 (2000 U) intrathecally to s...

3. Variability in the Oral Bioavailability of All-trans-Retinoic AcidVariability in the Oral Bioavailability of All-trans-Retinoic Acid

Background: Orally administered all-trans-retinoic acid (all-trans-RA) can induce complete remission in a high proportion of patients with acute promyelocytic leukemia....

4. Dose-Dependent Pharmacokinetics of All-trans-Retinoic AcidDose-Dependent Pharmacokinetics of All-trans-Retinoic Acid

Background: Orally administered all-trans-retinoic acid (all-trans-RA) can induce remission in a high proportion of patients with acute promyelocytic leukemia. Purpose

5. RESPONSE: Re: Treatment of Accidental Intrathecal Methotrexate Overdose

6. A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhood

A phase I trial was conducted to determine the maximum tolerated dose (MTD) of temozolomide given in combination with lomustine in newly diagnosed pediatric patients with high-grade gliomas. Response ...

7. Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: A Children's Oncology Group phase I study

The purpose of this study was to determine the dose-limiting toxicities, maximum tolerated dose, pharmacokinetics, and intratumor and brain distribution of motexafin gadolinium (MGd) with involved fie...

8. A phase 1 study of vinblastine in combination with carboplatin for children with low-grade gliomas: a Children's Oncology Group phase 1 consortium study

Both carboplatin and vinblastine have demonstrated single-agent activity in children with low-grade gliomas. A phase 1 trial evaluating 2 different schedules of these 2 agents in combination was perfo...